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There is now compelling evidence that the complexity of higher organisms correlates with the relative amount of non-coding RNA rather than the number of protein-coding genes. Previously dismissed as ¿junk DNA¿, it is the non-coding regions of the genome that are responsible for regulation, facilitating complex temporal and spatial gene expression through the combinatorial effect of numerous mechanisms and interactions working together to fine-tune gene expression. The major regions involved in regulation of a particular gene are the 5¿ and 3¿ untranslated regions and introns. In addition, pervasive transcription of complex genomes produces a variety of non-coding transcripts that interact with these regions and contribute to regulation. This book discusses recent insights into the regulatory roles of the untranslated gene regions and non-coding RNAs in the control of complex gene expression, as well as the implications of this in terms of organism complexity and evolution.¿
| Autorius: | Lucy W. Barrett, Steve D. Wilton, Sue Fletcher, |
| Serija: | SpringerBriefs in Biochemistry and Molecular Biology |
| Leidėjas: | Birkhäuser Basel |
| Išleidimo metai: | 2013 |
| Knygos puslapių skaičius: | 64 |
| ISBN-10: | 3034806787 |
| ISBN-13: | 9783034806787 |
| Formatas: | 235 x 155 x 4 mm. Knyga minkštu viršeliu |
| Kalba: | Anglų |
Parašykite atsiliepimą apie „Untranslated Gene Regions and Other Non-coding Elements: Regulation of Eukaryotic Gene Expression“
