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This thesis presents a simple, yet highly effective surface engineering solution that uses non-covalent binding peptides to control the autophagy-inducing activity of nanomaterials and nanodevices. The author presents RE-1, a short synthetic peptide that sequence-specifically binds to lanthanide (LN) oxide and upconversion nanocrystals with high affinity, which was discovered using an innovative phage display approach. RE-1 effectively inhibits the autophagy-inducing activity and toxicity of these nanocrystals by forming a stable coating layer on the surface of the nanoparticles, and by reducing their sedimentation and cell interaction. RE- 1 and its variants provide a versatile tool for tuning cell interactions in order to achieve the desired level of autophagic response and are useful for the various diagnostic and therapeutic applications of LN-based nanomaterials and nanodevices.
| Autorius: | Yunjiao Zhang |
| Serija: | Springer Theses |
| Leidėjas: | Springer Nature Singapore |
| Išleidimo metai: | 2023 |
| Knygos puslapių skaičius: | 172 |
| ISBN-10: | 9811681686 |
| ISBN-13: | 9789811681684 |
| Formatas: | 235 x 155 x 10 mm. Knyga minkštu viršeliu |
| Kalba: | Anglų |
Parašykite atsiliepimą apie „Tuning Autophagy-Inducing Activity and Toxicity for Lanthanide Nanocrystals“
