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Total Synthesis of Indole Alkaloids: Based on Direct Construction of Pyrrolocarbazole Scaffolds via Gold-Catalyzed Cascade Cyclizations

-15% su kodu: ENG15
143,97 
Įprasta kaina: 169,38 
-15% su kodu: ENG15
Kupono kodas: ENG15
Akcija baigiasi: 2025-03-03
-15% su kodu: ENG15
143,97 
Įprasta kaina: 169,38 
-15% su kodu: ENG15
Kupono kodas: ENG15
Akcija baigiasi: 2025-03-03
-15% su kodu: ENG15
2025-02-28 169.3800 InStock
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Knygos aprašymas

This book explores efficient syntheses of indole alkaloids based on gold-catalyzed cascade cyclizations, presenting two strategies for total synthesis of these natural products based on gold-catalyzed reactions of conjugated diyne or ynamide.
The book first describes the total and formal synthesis of dictyodendrins A¿F based on direct construction of the pyrrolo[2,3-c]carbazole core using the gold-catalyzed annulation of azido-diynes and protected pyrrole. This synthetic strategy features late-stage functionalization of the pyrrolo[2,3-c]carbazole scaffold at several positions and allows diverse access to dictyodendrins and their derivatives. Secondly, the book discusses the formal synthesis of vindorosine based on the pyrrolo[2,3-d]carbazole construction using the gold-catalyzed cascade cyclization of ynamide. Importantly, the reaction using a chiral gold complex provides the optically active pyrrolo[2,3-d]carbazole. This strategy facilitates the rapid construction of the pyrrolocarbazole core structure of aspidosperma and related alkaloids, including vindorosine.
These methodologies can accelerate the medicinal application of pyrrolocarbazole-type alkaloids and related compounds.

Informacija

Autorius: Junpei Matsuoka
Serija: Springer Theses
Leidėjas: Springer Nature Singapore
Išleidimo metai: 2020
Knygos puslapių skaičius: 96
ISBN-10: 9811586519
ISBN-13: 9789811586514
Formatas: 241 x 160 x 12 mm. Knyga kietu viršeliu
Kalba: Anglų

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