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The thymus is an evolutionarily ancient primary lymphoid organ common to all vertebrates in which T cell development takes place. Failing thymus function is associated with immunodeficiency and/or autoimmunity. In this volume, leading experts provide a comprehensive overview of recent advances in thymopoiesis research. The chapters cover the development of the thymic epithelial microenvironment, address the formation of a diverse and self-tolerant repertoire of T cell receptors as the basis for cellular immunity, discuss the mechanisms by which progenitor cells colonize the thymus and detail the molecular basis for T lineage decisions. The reviews illustrate the important role of the multifaceted process of thymopoiesis for adaptive immunity.
| Serija: | Current Topics in Microbiology and Immunology |
| Leidėjas: | Springer Berlin Heidelberg |
| Išleidimo metai: | 2013 |
| Knygos puslapių skaičius: | 140 |
| ISBN-10: | 3642402518 |
| ISBN-13: | 9783642402517 |
| Formatas: | 241 x 160 x 14 mm. Knyga kietu viršeliu |
| Kalba: | Anglų |
Parašykite atsiliepimą apie „Thymic Development and Selection of T Lymphocytes“
