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A comprehensive, state-of-the-art review of our current understanding of the molecular and structural biology of 5-HT receptors and their potential use for drug discovery. The authors describe the anatomical, cellular, and subcellular distribution of 5-HT receptors and demonstrate a powerful approach to elucidating their physiological role using knockout mice in which the 5-HT receptors were deleted. They also review our understanding of the physiological role(s) of 5-HT receptors based mainly on studies performed in genetically engineered mice. Highlights include discussions of the behavioral phenotypes of 5-HT receptor knockout animals, the molecular biology and pharmacology of 5-HT receptors, and insights into the complexity of 5-HT receptor signal transduction.
| Serija: | The Receptors |
| Leidėjas: | Humana Press |
| Išleidimo metai: | 2006 |
| Knygos puslapių skaičius: | 644 |
| ISBN-10: | 1588295680 |
| ISBN-13: | 9781588295682 |
| Formatas: | 235 x 157 x 44 mm. Knyga kietu viršeliu |
| Kalba: | Anglų |
Parašykite atsiliepimą apie „The Serotonin Receptors: From Molecular Pharmacology to Human Therapeutics“
