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Incretins are hormones released from the gut in response to nutrient ingestion that potentiate glucose-stimulated insulin secretion. The search for incretins was prompted by the observation that administration of an oral glucose load leads to a much greater stimulation of insulin response than that obtained when glucose is infused intravenously to give identical blood glucose levels . This difference between the two ways of glucose administration has been attributed to incretin hormones, glucagon-like peptide-1 (GLP-1) and glucose- dependant insulinotropic polypeptide (GIP), involved in the disposal of absorbed glucose, through the stimulation of insulin secretion.Indeed, GLP-1R agonists and DPP-4 inhibitors have been widely and successfully used therapeutic agents in the management of type 2 diabetes.
| Autorius: | Mehrevan Abd El-Moniem, Nadia Mohamed Ahmed, |
| Leidėjas: | LAP LAMBERT Academic Publishing |
| Išleidimo metai: | 2015 |
| Knygos puslapių skaičius: | 88 |
| ISBN-10: | 3659814369 |
| ISBN-13: | 9783659814365 |
| Formatas: | 220 x 150 x 6 mm. Knyga minkštu viršeliu |
| Kalba: | Anglų |
Parašykite atsiliepimą apie „The Physiological Effect of Incretin Hormones“
