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The sodium-coupled phosphate transporter NaPi-IIa is the main cellular carrier accomplishing kidney phosphate reabsorption. It is driven by the electrochemical Na+ gradient across the apical cell membrane, which is maintained by Na+ extrusion across the basolateral cell membrane through the Na+/K+ ATPase. Energy starvation is sensed by the AMPK, a serine/threonine kinase stimulating several cellular mechanisms increasing energy production and limiting energy consumption. AMPK provides a critical link between energy metabolism and cellular transport. The aging suppressor Klotho, a transmembrane protein, is a protease and hormone has been shown to exert a profound effect on phosphate metabolism, aging, and lifespan. Additionally, the enzymes SGK1, mTOR, Akt/PKB and Nedd4-2 are of critical importance for a wide variety of functions including bone mineralization and energy metabolism. The present book explores the mechanisms of phosphate homeostasis and the role of AMPK, Klotho, SGK1, mTOR, Akt/PKB and Nedd4-2 in the regulation of NaPi-IIa activity.
| Autorius: | Miribane Dërmaku-Sopjani, Mentor Sopjani, |
| Leidėjas: | LAP LAMBERT Academic Publishing |
| Išleidimo metai: | 2019 |
| Knygos puslapių skaičius: | 120 |
| ISBN-10: | 6139457777 |
| ISBN-13: | 9786139457779 |
| Formatas: | 220 x 150 x 8 mm. Knyga minkštu viršeliu |
| Kalba: | Anglų |
Parašykite atsiliepimą apie „The cotransporter NaPi-IIa: enzyme-dependent activity regulation: Cellular mechanisms and health effects“
