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The aqueous extract of Tectona grandis bark (ATG) was investigated for anti-inflammatory and antinociceptive activity at the doses (p.o.) of 100, 200 and 400 mg/kg body weight. The acetic acid-induced writhing response, tail immersion test and hot plate test were used to assess antino-ciceptive activity. For evaluation of anti-inflammatory activity, carrageenan induced paw edema served as acute model. At a dose, ATG (100, 200 and 400 mg/kg, p.o.) significantly attenuated the writhing responses induced by an intraperitoneal injection of acetic acid and at ATG (200 and 400 mg/kg, p.o.) significantly increased pain latencies in tail immersion and hot plate test. In addition, the higher doses of ATG (200 and 400 mg/kg, p.o.) were inhibited carrageenan induced paw edema. From acute oral toxicity studies (OECD-423 guidelines), no mortality was observed even at highest dose of ATG (2000 mg/kg, p.o.).
| Autorius: | Jitendra Bhangale, S. R. Chaudhari, S. R. Acharya, |
| Leidėjas: | LAP LAMBERT Academic Publishing |
| Išleidimo metai: | 2012 |
| Knygos puslapių skaičius: | 88 |
| ISBN-10: | 3659000604 |
| ISBN-13: | 9783659000607 |
| Formatas: | 220 x 150 x 6 mm. Knyga minkštu viršeliu |
| Kalba: | Anglų |
Parašykite atsiliepimą apie „Tectona Grandis - A Useful Herb: Sagwan - A medicinal Plant“
