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The use of antibiotics in the treatment of various infections of humans caused by microbes has been a great success. Over the past years there has been an increase in the resistance of microorganisms against a large number of drugs. Keeping in view the biological activity and medicinal importance of sulfonamides, new sulfonamides are being synthesized. This book describes the synthesis of N-benzyl-4-methylbenzenesulfonamide, its N-alkylated derivatives and evaluation of their anti-microbial activity. N-benzyl-4- methylbenzene sulfonamide was synthesized by the condensation of benzyl amine with p-toluene benzenesulfonylchloride. The solvent used for this reaction was water.N-alkylated derivatives were prepared by reacting N-benzyl-4-methylbenzenesulfonamide with different alkylating agents and sodium hydride using DMF as solvent. The synthesized compounds were characterized by different techniques like X-ray crystallography, FT-IR, Elemental analyzer and melting point. Evaluation of anti-microbial activity was carried out by employing deep well method against different bacterial strains.The synthesized compounds exhibited appreciable anti-microbial activity.
| Autorius: | Waqar Ahmad, Asia Butt, Islam Ullah Khan, |
| Leidėjas: | LAP LAMBERT Academic Publishing |
| Išleidimo metai: | 2012 |
| Knygos puslapių skaičius: | 104 |
| ISBN-10: | 3659155314 |
| ISBN-13: | 9783659155314 |
| Formatas: | 220 x 150 x 7 mm. Knyga minkštu viršeliu |
| Kalba: | Anglų |
Parašykite atsiliepimą apie „Sulfonamides: X-Ray Structures and Biological Studies: A new approach towards Biologically Active Compounds“
