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Structure¿Activity Relationships for Development of Neurokinin-3 Receptor Antagonists: Reducing Environmental Impact

-22% su kodu: BOOKS
132,12 
Įprasta kaina: 169,38 
-22% su kodu: BOOKS
Kupono kodas: BOOKS
Akcija baigiasi: 2025-03-10
-22% su kodu: BOOKS
132,12 
Įprasta kaina: 169,38 
-22% su kodu: BOOKS
Kupono kodas: BOOKS
Akcija baigiasi: 2025-03-10
-22% su kodu: BOOKS
2025-03-31 132.12 InStock
Nemokamas pristatymas į paštomatus per 11-15 darbo dienų užsakymams nuo 20,00 

Knygos aprašymas

This book explores the possible development of neurokinin-3 receptor (NK3R) antagonists with reduced environmental impact.
Pharmaceuticals are used to cure diseases and to alleviate symptoms in humans and animals. However, the stable, bioactive substances excreted by patients have unfavorable effects on non-target species. To overcome these disadvantages of these highly stable, potent substances, drug design to turn off bioactivity after release into the environment is needed.
The book describes the development of eco-friendly NK3R antagonists by introducing a labile functional moiety and substituting a scaffold. This resulted in a novel NK3R antagonist that oxidized into its inactive form when exposed to air. Further, the book presents an efficient and easily achievable synthetic method of creating triazolopiperazine scaffolds, as well as a structure¿activity relationship study involving scaffold hopping for decomposable motifs, which led to a novel photodegradable NK3R antagonist.
Demonstrating that it is possible to develop compounds that convert into their inactive forms under environmental conditions, this book is useful for anyone interested in therapeutic agents with reduced environmental impact.

Informacija

Autorius: Koki Yamamoto
Serija: Springer Theses
Leidėjas: Springer Nature Singapore
Išleidimo metai: 2020
Knygos puslapių skaičius: 100
ISBN-10: 9811529647
ISBN-13: 9789811529641
Formatas: 241 x 160 x 12 mm. Knyga kietu viršeliu
Kalba: Anglų

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