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The project work focuses on the organic reaction monitoring by DPPH on the synthesised eight compounds of two series having variable electronegative atoms X=O/S/NH which have been screened for CNS depression study by synergistic activity by standard drug. This project is a comparison between the SAR study with antioxidant potentiality by DPPH by using logP values with IC50 values with lambda max in UV.The logP value of 4-carboxamido phenyl thio urea (-0.31) is lesser than 2-carboxy phenyl thiourea (1.53) , so the same property arises during potentiality of lmax in UV. The logP value of 4-carboxy phenyl thiourea (0.84) is greater than 2-carboxamido phenyl urea (0.47), so antioxidant potentiality of IC50 value for 2-carboxamido phenyl urea is -661.18 ppm which is more effective than 4-carboxy phenyl thiourea which is 43.79 ppm.
| Autorius: | Dhrubo Jyoti Sen, Viraj P. Jatakiya, R. Badmanaban, |
| Leidėjas: | LAP LAMBERT Academic Publishing |
| Išleidimo metai: | 2012 |
| Knygos puslapių skaičius: | 80 |
| ISBN-10: | 3847325418 |
| ISBN-13: | 9783847325413 |
| Formatas: | 220 x 150 x 5 mm. Knyga minkštu viršeliu |
| Kalba: | Anglų |
Parašykite atsiliepimą apie „Reaction monitoring by DPPH: M.Pharm. (PharmChem) student Mr. Viraj P. Jatakiya did the project under the guidance of Dr. D.J. Sen & Dr. R.Badmanaban“
