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Pyrrole-Imidazole Alkaloids from Marine Sponges: Structural Variation and Cytotoxicity of (¿)-Dibromophakellstatin, Synthesis of Ugibohlin and Oroidin, and Studies Towards Oxocyclostylidol

-15% su kodu: ENG15
33,58 
Įprasta kaina: 39,51 
-15% su kodu: ENG15
Kupono kodas: ENG15
Akcija baigiasi: 2025-03-03
-15% su kodu: ENG15
33,58 
Įprasta kaina: 39,51 
-15% su kodu: ENG15
Kupono kodas: ENG15
Akcija baigiasi: 2025-03-03
-15% su kodu: ENG15
2025-02-28 39.5100 InStock
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Knygos aprašymas

Oroidin is considered to be the biogenetic key metabolite of the pyrroleimidazole alkaloids. Several syntheses are known to date, all of which contain steps with only moderate yields. For a study on its reactivity large quantities are needed. Therefore, an improved synthesis would be beneficial. In the present work two different known routes to 8 were investigated. By following the method developed in our group (via Sonogashira coupling) several analogues arose as new products. By treating the two deaminated analogs 1 and 4 with NBS in TFA, no cyclization to the phakellin skeleton 3 took place. Instead, pyrrole oxidation occurred (Scheme 1).

Informacija

Autorius: Rares-Petru Moldovan
Leidėjas: Cuvillier
Išleidimo metai: 2012
Knygos puslapių skaičius: 176
ISBN-10: 3954042282
ISBN-13: 9783954042289
Formatas: 210 x 148 x 10 mm. Knyga minkštu viršeliu
Kalba: Anglų

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