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Oroidin is considered to be the biogenetic key metabolite of the pyrroleimidazole alkaloids. Several syntheses are known to date, all of which contain steps with only moderate yields. For a study on its reactivity large quantities are needed. Therefore, an improved synthesis would be beneficial. In the present work two different known routes to 8 were investigated. By following the method developed in our group (via Sonogashira coupling) several analogues arose as new products. By treating the two deaminated analogs 1 and 4 with NBS in TFA, no cyclization to the phakellin skeleton 3 took place. Instead, pyrrole oxidation occurred (Scheme 1).
Autorius: | Rares-Petru Moldovan |
Leidėjas: | Cuvillier |
Išleidimo metai: | 2012 |
Knygos puslapių skaičius: | 176 |
ISBN-10: | 3954042282 |
ISBN-13: | 9783954042289 |
Formatas: | 210 x 148 x 10 mm. Knyga minkštu viršeliu |
Kalba: | Anglų |
Parašykite atsiliepimą apie „Pyrrole-Imidazole Alkaloids from Marine Sponges: Structural Variation and Cytotoxicity of (¿)-Dibromophakellstatin, Synthesis of Ugibohlin and Oroidin, and Studies Towards Oxocyclostylidol“