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Type 1 diabetes (T1DM) is an autoimmune disease characterized by immune destruction of insulin-producing pancreatic ¿ cells. This leads to dysfunctional regulation of blood glucose levels in T1DM patients. The destruction of ¿ -cells of Langerhans islets is caused by infiltration of dendritic cells, macrophages and T lymphocytes. Normally, genetic susceptibility (association) studies depend on assessing the role of genotype markers (typically SNPs) in the susceptibility to the disease of interest in a case- control or family based sample. Many genes associated with type 1 diabetes mellitus, CTLA-4, PTPN22, IL-10, IL-18, VIT-D receptor are one of the common confirmed T1DM susceptibility genes
| Autorius: | Ali Salim Al-Shehmany |
| Leidėjas: | LAP LAMBERT Academic Publishing |
| Išleidimo metai: | 2015 |
| Knygos puslapių skaičius: | 72 |
| ISBN-10: | 3659756377 |
| ISBN-13: | 9783659756375 |
| Formatas: | 220 x 150 x 5 mm. Knyga minkštu viršeliu |
| Kalba: | Anglų |
Parašykite atsiliepimą apie „Polymorphisms in some genes associated with type 1 diabetes mellitus“
