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The first line anti-tuberculosis drugs are known to cause dose related adverse drug reactions like peripheral neuritis and hepatotoxicity. The risk of getting peripheral neuritis have been avoided through a concomitant administration of pyridoxine; while hepatotoxicity remains to be a major adverse effect of anti- tuberculosis therapy. Research findings state reduction in the incidence of hepatotoxicity by exploring a potential link between biopharmaceutical pattern of anti-tuberculosis drugs and genetic polymorphism of the enzymes metabolizing them. Reportedly a significant correlation has been found by pooling the data through a meta-analysis.
Autorius: | Swati Modgil, Shivani Thakur, Rajat Rana, |
Leidėjas: | LAP LAMBERT Academic Publishing |
Išleidimo metai: | 2022 |
Knygos puslapių skaičius: | 52 |
ISBN-10: | 333002934X |
ISBN-13: | 9783330029347 |
Formatas: | 220 x 150 x 4 mm. Knyga minkštu viršeliu |
Kalba: | Anglų |
Parašykite atsiliepimą apie „Pharmacogenomic Effect on Biopharmaceutics of Anti-Tubercular Therapy: A Systematic Review“