Development of resistance has severely limited the choice of available antimalarial drugs, which clearly highlights the urgent need of novel chemotherapeutic agents for the treatment of malaria. The purpose of this study was to develop new potential antimalarial agents with Amino-quinoline ring. A series of novel Amino-quinoline Mannich base drug molecules have been synthesized.The synthesized molecules were evaluated for in vitro and in vivo antimalarial activity against the chloroquine sensitive 3D7 (West Africa) and RKL-2 strain of Plasmodium falciparum and rodent malaria parasite Plasmodium yoelii (strain N-67) in Swiss mice model.
Autorius: | Bhupendra Singh, Dipak Chetia, |
Leidėjas: | LAP LAMBERT Academic Publishing |
Išleidimo metai: | 2012 |
Knygos puslapių skaičius: | 80 |
ISBN-10: | 3659253715 |
ISBN-13: | 9783659253713 |
Formatas: | 220 x 150 x 5 mm. Knyga minkštu viršeliu |
Kalba: | Anglų |
Parašykite atsiliepimą apie „Novel Antimalarial Drugs: Study of Amino-quinoline Mannich Bases“