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A panel of internationally recognized research scientists and clinical investigators brings together a diverse collection of readily reproducible methods for identifying and quantifying a large number of specific genetic abnormalities associated with the broad spectrum of myeloid malignancies. Highlights include techniques for the detection of BCR-ABL mutations and resistance to imatinib mesylate, detection of the FIP1L1-PDGFRA fusion in idiopathic hypereosinophilic syndrome and chronic eosinophilic leukemia, classification of AML by DNA-oligonucleotide microarrays, and detection of the V617F JAK2 mutation in myeloproliferative disorders. In addition to gene rearrangments, other prognostically relevant molecular lesions such as FLT3 mutations and WT-1 overexpression are covered.
Serija: | Methods in Molecular Medicine |
Leidėjas: | Humana Press |
Išleidimo metai: | 2020 |
Knygos puslapių skaičius: | 320 |
ISBN-10: | 1607614561 |
ISBN-13: | 9781607614562 |
Formatas: | 235 x 155 x 18 mm. Knyga minkštu viršeliu |
Kalba: | Anglų |
Parašykite atsiliepimą apie „Myeloid Leukemia: Methods and Protocols“