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This book establishes the theoretical foundations of a general methodology for multiple hypothesis testing and discusses its software implementation in R and SAS. These are applied to a range of problems in biomedical and genomic research, including identification of differentially expressed and co-expressed genes in high-throughput gene expression experiments; tests of association between gene expression measures and biological annotation metadata; sequence analysis; and genetic mapping of complex traits using single nucleotide polymorphisms. The procedures are based on a test statistics joint null distribution and provide Type I error control in testing problems involving general data generating distributions, null hypotheses, and test statistics.
| Autorius: | Mark J. Van Der Laan, Sandrine Dudoit, |
| Serija: | Springer Series in Statistics |
| Leidėjas: | Springer US |
| Išleidimo metai: | 2007 |
| Knygos puslapių skaičius: | 628 |
| ISBN-10: | 0387493166 |
| ISBN-13: | 9780387493169 |
| Formatas: | 241 x 160 x 38 mm. Knyga kietu viršeliu |
| Kalba: | Anglų |
Parašykite atsiliepimą apie „Multiple Testing Procedures with Applications to Genomics“
