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Enzymes with multicopper active sites play important roles in many biological processes. Recently a novel multinuclear copper site was discovered in N2O-Reductase and its exact structure and mechanism has been much discussed since then. The so called CuZ center contains a unique tetranuclear Cu4S2-Cluster, which is coordinated by seven histidine residues. Until now no synthetic model complex could be isolated that emulates the Cu4S2 core of the active site. In this thesis a new strategy towards such model systems is introduced. To mimic the nitrogen-rich environment of the copper ions, pyrazolate-based ligand scaffolds with chelating N-donor side arms are employed. The resulting binuclear metal complexes were isolated and fully characterized. Additionally the reactivity of these binuclear building blocks towards various sulfur-containing coligands and sulfur-transfer reagents was investigated.
| Autorius: | Vera Konstanzer |
| Leidėjas: | Cuvillier |
| Išleidimo metai: | 2011 |
| Knygos puslapių skaičius: | 206 |
| ISBN-10: | 3869559780 |
| ISBN-13: | 9783869559780 |
| Formatas: | 210 x 148 x 11 mm. Knyga minkštu viršeliu |
| Kalba: | Anglų |
Parašykite atsiliepimą apie „Multinuclear Pyrazolate-Based Copper Complexes Inspired by the CuZ-Site of N2O-Reductases“
