Atnaujintas knygų su minimaliais defektais pasiūlymas! Naršykite ČIA >>
Beschreibung The recent rise of bio-succinic acid as an industrial platform chemical has brought the rumen bacterium Basfia succiniciproducens, a natural producer of this organic acid, into the focus of research. This work investigated the potential of B. succiniciproducens for the production of carbon-three chemicals from sugars. Beside the optimization of improved genetic tools, the C3 chemicals alanine, ¿-alanine and 3-hydroxypropionate (3-HP) were targeted. A new alanine producer, B. succiniciproducens ALA-1, exhibited good performance in the bioprocess. The next step demonstrated the proof-of-concept for ¿-alanine synthesis using the heterologous expression of aspartate 1 decarboxylase genes from Corynebacterium glutamicum or Vibrio natriegens. The expression of two additional genes enabled the de novo synthesis of up to 100 mg L-1 3-HP from glucose.
| Autorius: | Jonathan Thomas Fabarius |
| Serija: | Hochschulschriften - Institut für Biotechnologie, Universität des Saarlandes |
| Leidėjas: | Cuvillier |
| Išleidimo metai: | 2018 |
| Knygos puslapių skaičius: | 144 |
| ISBN-10: | 3736999135 |
| ISBN-13: | 9783736999138 |
| Formatas: | 210 x 148 x 9 mm. Knyga minkštu viršeliu |
| Kalba: | Anglų |
Parašykite atsiliepimą apie „Metabolic engineering of Basfia succiniciproducens for the production of carbon-three compounds (Band 7)“
