Meta-analysis of the association of NRXN1 variants and Psychotic Spectrum Disorders

Academic Paper from the year 2017 in the subject Medicine - Neurology, Psychiatry, Addiction, grade: -, University of Murcia, language: English, abstract: Objective: To perform a meta-analysis of all published genetic association studies of NRNX1 variants and psychotic spectrum disorders (PSD). Methods: Potential studies were identified through PubMed/MEDLINE, EMBASE, HuGeNet, GeneCard and WoS up from 1980 until June 2015 (week 5). Published observational studies reporting NRXN1 variants in PSD cases and in non-PSD controls were all considered eligible for inclusion in this systematic review. Two reviewers selected studies for possible inclusion and extracted data independently following a standardized protocol. Different meta-analyses were performed for each NRXN1 variant and PSD and controls, with a random-effect model to calculate the pooled OR and its corresponding 95% CI. Forest plots and Cochran¿s Q-Statistic and I2 index were calculated to check for heterogeneity. Subgroup analyses and chi-square test were carried out to analyze potential moderators. Publication bias and quality of reporting were also analyzed. Results: 19 studies met our inclusion criteria, providing a total sample of 25208 patients with PSD and 56971 controls. Meta-analyses of NRXN1 deletions (OR = 3.36), exons (OR = 3.53) and introns (OR = 2.02) showed evidence of an association between NRXN1 gene and PSD. Only one study influed in a meta-analysis (NRXN1 deletions) and no quality criterion affected as moderating variable. There was evidence of potential publication bias in NRXN1 deletions, exonic and promoter meta-analyses. Conclusions: We found association between some variants of the NRXN1 gene and PSD. It¿s important to develop a greater effort for the study of the NRXN1 gene and bigger number of studies that will clarify it¿s association. The appendix is in Spanish.