This brief discusses the mechanism of functional expression of a protein or protein complex utilizing the ATP hydrolysis cycle or proton-motive force from a unique point of view focused on the roles of water. A variety of processes are considered such as the unidirectional movement of a linear-motor protein along a filament, insertion of an unfolded protein into a chaperonin and release of the folded protein from it, transport of diverse substrates across the membrane by a transporter, and directed rotation of the central subunit within a rotatory motor protein complex. These topics are discussed in a unified manner within the same theoretical framework. The author argues that water plays imperative roles in the functional expression of these molecular machines. A pivotal factor is the entropic force or potential originating from the translational displacement of water molecules coexisting with the molecular machines in the entire system.
| Autorius: | Masahiro Kinoshita |
| Serija: | SpringerBriefs in Molecular Science |
| Leidėjas: | Springer Nature Singapore |
| Išleidimo metai: | 2016 |
| Knygos puslapių skaičius: | 80 |
| ISBN-10: | 9811014841 |
| ISBN-13: | 9789811014840 |
| Formatas: | 235 x 155 x 5 mm. Knyga minkštu viršeliu |
| Kalba: | Anglų |
Parašykite atsiliepimą apie „Mechanism of Functional Expression of the Molecular Machines“
