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This book is the first one written about the JAK/STAT pathway. The JAK (Janus Kinase) Protein tyrosine kinases are novel phosphotransferases absolutely required for cellular signalling downstream of non-catalytic cytokine receptors (amongst others). These molecules are components in pathways utilising the STAT (Signal Transducers and Activators of Transcription) transcription factors. The basic components of the JAK/STAT pathway are covered in detail, and the centre piece of the book is a guided tour of the pathway itself. An interesting addition to the book is the chapter on the use of Drosophila melanogaster as a genetic system to probe the pathway at the whole organism level. The book is targeted to researchers who have an interest in intracellular signalling.
| Autorius: | Ailsa G. Harpur, Andrew F. Wilks, |
| Serija: | Molecular Biology Intelligence Unit |
| Leidėjas: | Springer Berlin Heidelberg |
| Išleidimo metai: | 2013 |
| Knygos puslapių skaičius: | 220 |
| ISBN-10: | 3662220520 |
| ISBN-13: | 9783662220528 |
| Formatas: | 254 x 178 x 13 mm. Knyga minkštu viršeliu |
| Kalba: | Anglų |
Parašykite atsiliepimą apie „Intracellular Signal Transduction: The JAK-STAT Pathway“
