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In vertebrates, the integrin family includes 24 members. As the alpha-chains were sequenced, some were observed to have an inserted domain similar to the A domain in several matrix and complement proteins. This inserted ligand binding domain is interactive and was called the I domain in integrins. More recently structural data have shown that an integrin beta-chain also contains an I domain. Nine of the currently known 18 alpha-chains contain an I domain. This book systematically goes through the current knowledge about these integrins, including the newest additions to the integrin family, the collagen-binding alpha10beta1 and alpha11beta1 integrins. The book discusses ligand binding, signalling properties, knock-out phenotypes and possible involvement in disease. This book comprehensively reviews the current knowledge about I domains in integrins and will serve as a useful reference book for scientists in this field.
| Serija: | Molecular Biology Intelligence Unit |
| Leidėjas: | Springer US |
| Išleidimo metai: | 2003 |
| Knygos puslapių skaičius: | 200 |
| ISBN-10: | 0306478366 |
| ISBN-13: | 9780306478369 |
| Formatas: | 235 x 157 x 17 mm. Knyga kietu viršeliu |
| Kalba: | Anglų |
Parašykite atsiliepimą apie „I Domains in Integrins“
