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The Signal Transducer and Activator of Transcription 1 (STAT1) is activated in response to interferons (IFNs) stimulations. In response to IFN-¿, STAT1 homodimerizes to form the gamma activating factor (GAF). In response to IFN-¿, STAT1 heterotrimerizes with STAT2 and ISGF3-¿ to form the interferon sequence gene factor 3 (ISGF3). This work clearly demonstrates the distinct roles of the IFN-¿-induced-GAF complexes in anti-mycobacterial immunity and of IFN-¿ induced- ISGF3 complexes in the anti-viral immunity in humans at the cellular and clinical levels by different molecular mechanisms. It also highlights the fact that a phenotype depends of the mutation and not only of the affected gene; and moreover the importance of the homozygosis or heterozygosis state of the mutation in human genetic diseases.
| Autorius: | Ariane Chapgier |
| Leidėjas: | LAP LAMBERT Academic Publishing |
| Išleidimo metai: | 2011 |
| Knygos puslapių skaičius: | 136 |
| ISBN-10: | 3844301682 |
| ISBN-13: | 9783844301687 |
| Formatas: | 220 x 150 x 9 mm. Knyga minkštu viršeliu |
| Kalba: | Anglų |
Parašykite atsiliepimą apie „Human STAT1 deficiencies: Description and characterisation of the different Human STAT1 deficiencies“
