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Diabetes mellitus (DM) is a world-wide endemic with increasing prevalence in both developing and developed countries in a common cause of disability and death all over the world .The outburst of diabetes in the word is mainly due to type 2 diabetes about (90 - 95%). Its specific etiology is not yet known its frequency varies in different racial and ethnic subgroups and is often associated with a strong familial, likely genetic predisposition. It was denoted that type2 DM was associated with certain HLA class II alleles were analyzed for their genotyping by Polymerase Chain Reaction-Sequences Specific Olegionucleotide (PCR-SSO) technique. The present study revealed that diabetic patients were positively associated with HLA-DQB1*0201 (83% vs. 5.0%) which is the most prevalent in patients followed by DRB1*1137 (46.7% vs. 0.0%); DRB1*0401 (41.7% vs. 2.5%),and DRB1*1306(15% vs.0.0%) while HLA,A*0201;B*3559;Cw*0410 and DQB1*0501 is negatively associated in type 2DM in comparison to healthy control groups. This study has shown that there is no significant association between FBS,HbA1c,serum insulin,HOMA2 ß-function , HOMA2-IR ,serum adiponectin ,serum adenosine deaminase and HLA alleles .
| Autorius: | Ahmed Kadhim Mohammed, Batool H. AL-Ghurabi, Mohammed I. Nader, |
| Leidėjas: | SPS |
| Išleidimo metai: | 2015 |
| Knygos puslapių skaičius: | 136 |
| ISBN-10: | 3639766814 |
| ISBN-13: | 9783639766813 |
| Formatas: | 220 x 150 x 9 mm. Knyga minkštu viršeliu |
| Kalba: | Anglų |
Parašykite atsiliepimą apie „HLA Class I and II Molecules in Type 2 Diabetic Iraqi patients: Geno-typing of HLA Class I and II Molecules in Type 2 Diabetic Iraqi Patients“
