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¿Breast cancer is the most frequently diagnosed cancer and the leading cause of cancer death in women worldwide, accounting for nearly a quarter of the total new cancer cases each year. Of these cases, approximately 15¿25% overexpress HER2, a transmembrane RTK kinase that is associated with aggressive tumor growth and poor outcomes. However, in the past decade, survival rates of patients with HER-positive breast cancer have significantly improved due to increased screening, HER2 testing, and breakthrough HER2-targeted drug therapies. Handbook of HER2-Targeted Agents in Breast Cancer provides oncologists, primary care physicians, trainees and other healthcare providers with a concise, accessible, and up-to-date survey of the field, including a review of our current understanding of the biology of the HER2 pathway and the rationale for targeting it in early-stage and advanced breast cancer, an overview of HER2-testing, and evidence-based discussions of available HER2-targeted regimens in the adjuvant and metastatic settings.
| Autorius: | Ricardo H Alvarez, Stefania Zambelli, Michael Gandy, Javier Cortés, Leticia Mattos-Arruda, Mary Falzon, Angelica Fasolo, Dimitrios Zardavas, Luca Gianni, Nadia, |
| Leidėjas: | Springer Healthcare Ltd. |
| Išleidimo metai: | 2014 |
| Knygos puslapių skaičius: | 108 |
| ISBN-10: | 1907673938 |
| ISBN-13: | 9781907673931 |
| Formatas: | 201 x 127 x 7 mm. Knyga minkštu viršeliu |
| Kalba: | Anglų |
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