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The hepatitis C virus (HCV), the silent killer, is endemic worldwide. Therefor, finding novel signatures for HCV progression and response to anti-viral therapies is very important in terms of diagnosis and prognosis of the disease. P53 induces the expression of Fas for triggering apoptosis; an important mechanism for limiting viral replication. This study aims at investigating the impact of P53 rs 1042522 and Fas rs 1800682 genetic polymorphisms at 72 Arg/Pro and -670 A/G respectively on HCV susceptibility and treatment response. Quantitation of HCV-RNA by qRT-PCR and histological scores were performed for every patient, as well as genotyping of HCV-RNA, P53 at 72 Arg/Pro, and Fas at -670 A/G polymorphisms were done for all subjects. In addition, hormonal profiling for all patients and controls were investigated and correlated with the genetic signatures, providing a strong multi-signatures for HCV progression and response.
| Autorius: | Ahmed A. Abd-Rabou, Emad F. Eskander, |
| Leidėjas: | LAP LAMBERT Academic Publishing |
| Išleidimo metai: | 2015 |
| Knygos puslapių skaičius: | 220 |
| ISBN-10: | 3659770566 |
| ISBN-13: | 9783659770562 |
| Formatas: | 220 x 150 x 14 mm. Knyga minkštu viršeliu |
| Kalba: | Anglų |
Parašykite atsiliepimą apie „Genetic Signatures for Progression and Response of Hepatitis C: Apoptosis and Hepatitis C: Genetic and Hormonal Predictors“
