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In this book, we explore the potential applications of functionalized folic acid-polymer nanoparticles in gene and drug delivery. Folic acid-chitosan (carbohydrates) and folic acid-PAMAM (dendrimers) of different sizes were used to transport DNA, RNA and drugs in vitro. Thermodynamic analysis showed conjugation of DNA, RNA and drug to nanoparticles occurred via hydrophilic, hydrophobic, H-bonding and van der Waals contacts. Major alterations of DNA and RNA morphology occurred by nanocarrier interaction, while drugs induced polymer morphological changes. Functionalized folic acid-nanoparticles can deliver DNA, RNA and drugs to the target molecules.
| Autorius: | Heidar-Ali Tajmir-Riahi |
| Leidėjas: | Éditions universitaires européennes |
| Išleidimo metai: | 2018 |
| Knygos puslapių skaičius: | 192 |
| ISBN-10: | 6202289600 |
| ISBN-13: | 9786202289603 |
| Formatas: | 220 x 150 x 12 mm. Knyga minkštu viršeliu |
| Kalba: | Anglų |
Parašykite atsiliepimą apie „Gene and Drug Delivery by Natural and Synthetic Nanoparticles“
