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The aim of the present research work was to develop and formulate a bilayer floating sustained release tablet of Nifedipine. Nifedipine is an antihypertensive agent. Surface solid dispersion of Nifedipine was prepared by solvent evaporation method with different super disintegrants as a polymer for improvement of solubility resulting in improved bioavailability. Bilayer consists of two layers, immediate-release layer, and second sustained release layer, compressed in the single unit dosage form. The immediate-release layer contains surface solid dispersion of Nifedipine. The floating sustained release layer also contains surface solid dispersion of Nifedipine, HPMC K100M & HPMC K15M as sustained release polymer. The floating properties of the tablets were achieved by the use of sodium bicarbonate & citric acid which generate the gas upon contact with gastric fluid. The immediate-release layer releases the drug immediately and starts the onset of action and the floating sustained release layer floats on gastric fluid for upto12 hours and releases the drug in a sustained manner, subsequently, it prolongs the duration of action.
| Autorius: | Dinesh Kumar Sharma, Amulyaratna Behera, Gurudutta Pattnaik, |
| Leidėjas: | LAP LAMBERT Academic Publishing |
| Išleidimo metai: | 2021 |
| Knygos puslapių skaičius: | 108 |
| ISBN-10: | 620341087X |
| ISBN-13: | 9786203410877 |
| Formatas: | 220 x 150 x 8 mm. Knyga minkštu viršeliu |
| Kalba: | Anglų |
Parašykite atsiliepimą apie „Formulation and Development of Bilayer Floating Tablets of Nifedipine: Formulation and Development of Bilayer Floating Tablets of Nifedipine Using Surface Solid Dispersion Technique“
