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Type 2 diabetes mellitus (T2DM) represents about 90% of diabetic cases. Diabetic nephropathy is one of the most serious complications of diabetes. Sitagliptin has an important role in enhancement of the Glucagon-like peptide receptor (GLP-1R) which present in the kidneys, so it may have a role in enhancement of the kidney function in T2DM. Also, Punica granatum peels extract (PGPE) is a herb which has an anti-hyperglycemic and antioxidant activities. This study was designed to investigate the role of PGPE and/or sitagliptin on renal functions in induced diabetes. Results of the present work showed that administration of streptozotocin-nicotinamide induced oxidative stress, inflammation and hyperglycemia which play a significant role in diabetes and its complications. The improvement is due to the antidiabetic, anti-inflammatory, and antioxidative actions of sitagliptin and Punica granatum peels. The combination of Punica granatum and sitagliptin compared to monotherapy have better renoprotective effects in diabetic rats.
| Autorius: | Hanan Mohamed |
| Leidėjas: | LAP LAMBERT Academic Publishing |
| Išleidimo metai: | 2020 |
| Knygos puslapių skaičius: | 208 |
| ISBN-10: | 6203041068 |
| ISBN-13: | 9786203041064 |
| Formatas: | 220 x 150 x 13 mm. Knyga minkštu viršeliu |
| Kalba: | Anglų |
Parašykite atsiliepimą apie „Effects of Punica granatum and/ or Sitagliptin on diabetic nephropathy in male rats“
