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This collection explores detailed experimental protocols necessary for setting up a variety of in vitro cytochrome P450 (CYP) assays that are vital in selecting drug candidates in a drug discovery pipeline. Major factors affecting drug metabolism include CYP expression levels, kinetic parameters for individual CYP enzymes, CYP inhibition and induction, time-dependent inhibition (TDI), CYP stability, non-CYP stability, UDP-glucuronosyltransferases (UGT) stability, excretion mechanisms, and drug-drug interactions (DDI), all addressed in this volume. Written for the Methods in Pharmacology and Toxicology series, chapters include helpful background information on the in vitro assay, a list of all the materials, reagents, and equipment necessary to carry out the assay, a step-by-step protocol, notes containing common and unexpected experimental problems in the assay, as well as references containing important supplementary reading.
| Serija: | Methods in Pharmacology and Toxicology |
| Leidėjas: | Springer New York |
| Išleidimo metai: | 2022 |
| Knygos puslapių skaičius: | 392 |
| ISBN-10: | 1071615440 |
| ISBN-13: | 9781071615447 |
| Formatas: | 254 x 178 x 22 mm. Knyga minkštu viršeliu |
| Kalba: | Anglų |
Parašykite atsiliepimą apie „Cytochrome P450: In Vitro Methods and Protocols“
