This thesis presents a novel coarse-grained model of DNA, in which bases are represented as rigid nucleotides. The model is shown to quantitatively reproduce many phenomena, including elastic properties of the double-stranded state, hairpin formation in single strands and hybridization of pairs of strands to form duplexes, the first time such a wide range of properties has been captured by a coarse-grained model. The scope and potential of the model is demonstrated by simulating DNA tweezers, an iconic nanodevice, and a two-footed DNA walker ¿ the first time that coarse-grained modelling has been applied to dynamic DNA nanotechnology.
Autorius: | Thomas E. Ouldridge |
Serija: | Springer Theses |
Leidėjas: | Springer Berlin Heidelberg |
Išleidimo metai: | 2012 |
Knygos puslapių skaičius: | 188 |
ISBN-10: | 3642305164 |
ISBN-13: | 9783642305160 |
Formatas: | 241 x 160 x 15 mm. Knyga kietu viršeliu |
Kalba: | Anglų |
Parašykite atsiliepimą apie „Coarse-Grained Modelling of DNA and DNA Self-Assembly“