The present work aims to study effect of diff. viscosity grade of HPMC on cefixime trihydrate sustained release matrix tablet with a view to prolong drug release in vivo & reduce frequency of dosing. Cefixime Trihydrate is an orally active third generation cephalosporin and active against Gram+ve as well as Gram -ve bacteria. It has plasma half-life of 3-4 hrs. The Sustained release matrix tablets were prepared by wet granulation method using diff. grade of HPMC, Lactose, MCC & PVP K-30. The granules were subjected to pre-compression & post-compression parameters and they were in the acceptable limits. The in vitro drug release from HPMC matrices in accordance with its diff. proportion and viscosity grade was HPMC K-100M > K-15M > K-4M with ratio of (1, 1.5, 2) individually in formulation F1-F9 and (0.5, 0.75, 1) ratio in F10-F12. Drug-excipient interaction was performed by DSC & FTIR; results were shown that there was no interaction. After 3 months stability study at 400C/75% RH, formulations found to be stable. So as the viscosity and proportion of HPMC increases release rate from sustained release cefixime trihydrate matrix tablet decreases.
| Autorius: | Parth Patel, Kinjal Patel, |
| Leidėjas: | Scholars' Press |
| Išleidimo metai: | 2013 |
| Knygos puslapių skaičius: | 112 |
| ISBN-10: | 3639515536 |
| ISBN-13: | 9783639515534 |
| Formatas: | 220 x 150 x 7 mm. Knyga minkštu viršeliu |
| Kalba: | Anglų |
Parašykite atsiliepimą apie „Cefixime Trihydrate Sustained Release Matrix Tablet: To study the effect of different viscosity grade of HPMC on Cefixime Trihydrate sustained Release Matrix Tablet“
