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In addition to working together to drive expression of target genes, ¿-catenin and TCF often work independently of each other. They both regulate several stages of T cell development, but their mode of action remains poorly understood. To study the specific role of ¿-catenin-TCF interactions in T cells, we generated transgenic mice that express ICAT, a naturally occurring inhibitor of ¿-catenin-TCF interactions, in the T cell lineage. We found that ¿-catenin-TCF interactions are important for thymocyte survival, but not for proliferation or differentiation. Interestingly, thymocyte aging slows down in ICAT-Tg mice, suggesting a role for ¿-catenin-TCF interactions in normal thymic involution. We also discovered that ¿-catenin-TCF interactions provide survival signals to activated T cells and promote differentiation of activated CD4 T cells into the default Th2 lineage. However, TCF represses Th1 differentiation independently of its interaction with ¿-catenin. This study, thus, provides novel insights into the role of ¿-catenin and TCF in T cell development, function, and aging, and should of interest to immunologists, developmental biologists, and gerontologists alike.
| Autorius: | Mohammad Zulfiquer Hossain |
| Leidėjas: | LAP LAMBERT Academic Publishing |
| Išleidimo metai: | 2009 |
| Knygos puslapių skaičius: | 196 |
| ISBN-10: | 3838334507 |
| ISBN-13: | 9783838334509 |
| Formatas: | 220 x 150 x 12 mm. Knyga minkštu viršeliu |
| Kalba: | Anglų |
Parašykite atsiliepimą apie „¿-Catenin, TCF, and ICAT: Novel Roles in T Cell Development, Function, and Aging“
