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Carcinogenesis is a multi-aetiological process involving alterations of key biomolecular markers. These are recognised by the humoral system and known as Tumour Associated Antigens (TAA) against which the humoral system mounts an auto-antibody response. Cancer cells are subject to two key mortality barriers (M1 & M2) as described in the ¿2-hit¿ hypothesis. These are overcome by p53 dysfunction in M1 and hTERT re-expression in M2. Auto-antibodies are produced in response to these two TAA. This book investigates the significance of the anti-p53 and anti-hTERT auto-antibody response. The initial literature review of anti-p53 auto-antibody in all cancers (1979-2010) forms the largest body of evidence of correlation between anti-p53 auto-antibody and p53 mutation to date. This is followed by results of our anti-p53 study and evaluation of all published studies of anti-p53 in colorectal cancer. Anti-hTERT has only been reported once, using molecular recombination to develop the hTERT antigen. The latter section of this book aims to develop a less restrictive technology for mass detection of anti-hTERT. This humoral response could enable earlier identification of CRC and impact prognosis.
| Autorius: | Aravind Suppiah |
| Leidėjas: | Scholars' Press |
| Išleidimo metai: | 2013 |
| Knygos puslapių skaičius: | 272 |
| ISBN-10: | 363951520X |
| ISBN-13: | 9783639515206 |
| Formatas: | 220 x 150 x 17 mm. Knyga minkštu viršeliu |
| Kalba: | Anglų |
Parašykite atsiliepimą apie „Auto-immunity in Colorectal Cancer: Anti-p53 and anti-hTERT antibody“
