Due to poor drug solubility and absorption, many drug candidates fall short of expectations. Self-emulsifying drug delivery methods increase the solubility and bioavailability of poorly soluble medications. When SEDDS are added to an aqueous phase and gently mixed, fine oil-in-water emulsions form. SEDDS come in soft or hard gelatin capsules for oral administration and form fine, stable oil-in-water emulsions. SEDDS are primarily manufactured as liquid formulations, which have poor stability and mobility, low drug loading, a limited number of dosage form options, irreversible drug/excipient precipitation, and a high proportion (30¿60%) of surfactants that might irritate the gastrointestinal system. Solid-SEDDS has been studied to avoid the problems of liquid SEDDS. The adsorption of liquid self-micro-emulsified formulations on solid carriers is one of the best ways to create free-flowing powders for compression into tablet dosage form (SMET).
| Autorius: | Prasanta Kumar Biswal, Prafulla Kumar Sahu, |
| Leidėjas: | LAP LAMBERT Academic Publishing |
| Išleidimo metai: | 2022 |
| Knygos puslapių skaičius: | 76 |
| ISBN-10: | 6205528088 |
| ISBN-13: | 9786205528082 |
| Formatas: | 220 x 150 x 5 mm. Knyga minkštu viršeliu |
| Kalba: | Anglų |
Parašykite atsiliepimą apie „ATORVASTATIN SELF-EMULSIFIED TABLETS FORMULATION AND EVALUATION: SELF-EMULSIFIED DRUG DELIVERY SYSTEM“
