This thesis addresses two fundamental areas in contemporary organic chemistry: synthesis of natural products and catalytic asymmetric synthesis. Firstly, a new methodology, developed by our research group, which allows the asymmetric synthesis of lactones, a structural unit ubiquitous in natural products, was utilised in the synthesis of a number of natural product analogues that showed significant biological activity. Secondly, the development of a catalytic asymmetric synthesis of a key structural motif present in a number of natural products and pharmaceuticals was accomplished. During the course of this work we discovered dual stereo control, which is significant because it allows the configuration of a new stereo centre to be controlled by a simple change of proton source.
| Autorius: | Robert Doran |
| Serija: | Springer Theses |
| Leidėjas: | Springer Nature Switzerland |
| Išleidimo metai: | 2015 |
| Knygos puslapių skaičius: | 224 |
| ISBN-10: | 3319205439 |
| ISBN-13: | 9783319205434 |
| Formatas: | 241 x 160 x 18 mm. Knyga kietu viršeliu |
| Kalba: | Anglų |
Parašykite atsiliepimą apie „Asymmetric Synthesis of Bioactive Lactones and the Development of a Catalytic Asymmetric Synthesis of ¿-Aryl Ketones“
