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Adiponectin is the name originated from its distinctive molecular characteristics (¿adipö + ¿nectin¿ = ¿adiponectin¿) as it is a product of novel gene apM1 which is specific to adipocytes and uniquely possess a collagen-like domain with a nectin-like adherent property. Adiponectin is the most abundant peptide secreted by adipocytes, whose altered levels play a central role in obesity-related diseases, including insulin resistance/type 2 diabetes and cardiovascular disease. It is known to exert anti-diabetic and anti-atherosclerotic effects via adiponectin receptors (Adipors); AdipoR1 and AdipoR2. Adiponectin has direct actions in liver, skeletal muscle and the vasculature. Adiponectin administration in humans and rodents has insulin-sensitizing, anti-atherogenic, and anti-in¿ammatory effects and in certain settings, also decreases body weight. Therefore, adiponectin replacement therapy in humans may suggest potential versatile therapeutic targets in the treatment of obesity, insulin resistance/type 2 diabetes, cardiovascular disease and atherosclerosis.
| Autorius: | Seema Gupta, V. N. Satyawali, Sanjeev Kumar Shukla, |
| Leidėjas: | Scholars' Press |
| Išleidimo metai: | 2020 |
| Knygos puslapių skaičius: | 68 |
| ISBN-10: | 6138920910 |
| ISBN-13: | 9786138920915 |
| Formatas: | 220 x 150 x 5 mm. Knyga minkštu viršeliu |
| Kalba: | Anglų |
Parašykite atsiliepimą apie „Adiponectin : Implications in Health and Diseases: Adiponectin“
