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The activities of flavonoid are believed to increase when they are coordinated with transition metal ions. An attempt was made to understand the contribution of the metal coordination & type of interaction between a flavonoid & metal ion & evaluation of its biological activity. In this study a new metal complex of Co(II) with naringin was synthesized & characterized by FT-IR, UV-VIS spectrophotometer. Groups of six mice were treated with Cobalt Naringin Complex (10 mg/kg body weight), administered IP. Different tests were used for evaluating the anti-nociceptive effect or the influence on behavior of the tested substances on thermal nociception, chemical nociception & spontaneous behavior. In the current study it has been evaluated that the complex has a Co(II) ion coordinated via 4 and 5 position of the flavonoid. The metal binds with the flavonoid in the ratio 1:2, which was confirmed by Jobs method. Our preliminary data for response latencies for hot-plate and tail- flick tests suggest that systemically administered CNC produces a significant analgesic effect under thermal thermal nociceptive stimulation. The spontaneous behavior assay shows a significant decrease of activity.
| Autorius: | Rudra Narayan Sahoo, Lipsa Samal, Sudhanshu Sekhar Rout, |
| Leidėjas: | LAP LAMBERT Academic Publishing |
| Išleidimo metai: | 2021 |
| Knygos puslapių skaičius: | 56 |
| ISBN-10: | 6203201340 |
| ISBN-13: | 9786203201345 |
| Formatas: | 220 x 150 x 4 mm. Knyga minkštu viršeliu |
| Kalba: | Anglų |
Parašykite atsiliepimą apie „Activities of Naringin-co (II) Metal Complexes: Anti-nociceptive: Anti-nociceptive Activity of Naringin-co (II) Metal Complexes“
